Ambroxol or Mucolite
Ambroxol is an active metabolite of bromhexine, and it is used orally in the dose of 15mg thrice daily as an alternative to bromhexine.
It is used as an antitussive or an anti cough medicine. It increases the wateriness of respiratory secretions by causing mucolysis. This in turn assists in clearing infection from the respiratory tract by clearing and thinning the sputum.
This beneficial use of Ambroxol helps in thing the sputum and decreases the intensity of the cough.
Ambroxol mechanism of action
It is a strong inhibitor of the Na+ channels.
It relieves pain in throat inflammation, with a rapid onset of action. The effect of this mucolytic lasts for a minimum of 3 hours.
It also has anti-inflammatory action that reduces inflammation in an upper respiratory infection.
It must be remembered that cough serves the useful purpose of clearing the respiratory tract. It should not be severely obstructed in patients with a productive cough.
Use of antitussives in sedated or debilitated patients may prove dangerous. They should be used cautiously in the acute phase of pertussis and bronchial asthma, as inspissation of mucus plugs may contribute to a fatal outcome.
- Dry powders form
- Inhalation solution,
- Effervescent tablets.